Anti-SIGMAR1 Antibody
Catalog No : IGX-43369
262.00€
188.00€
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| Description | Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PMID:16472803, PMID:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 . | ||
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| Other names | Sigma non-opioid intracellular receptor 1, Aging-associated gene 8 protein, SR31747-binding protein, SR-BP, Sigma 1-type opioid receptor, SIG-1R, Sigma1-receptor, Sigma1R, hSigmaR1, SIGMAR1, OPRS1 SRBP | ||
| Cellular localization | Nucleus Inner Membrane, Nucleus Outer Membrane, Nucleus Envelope, Membrane, Postsynaptic Density Membrane, Endoplasmic Reticulum Membrane, Cytoplasmic Vesicle, Membrane, Single-Pass Membrane, Lipid Droplet, Cell Junction, Growth Cone | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q99720 | ||
| Product name | Anti-SIGMAR1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43369 | ||
| Supplier’s Catalog No | IGX-43369 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Sigma non-opioid intracellular receptor 1 protein (112-169AA) | ||
| Specificity | SIGMAR1 antibody detects endogenous level of SIGMAR1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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