Anti-CYP11B2 / Cytochrome P450 11B2 Antibody (Aldosterone synthase)
Catalog No : IGX-43269
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone (PMID:11856349, PMID:23322723, PMID:1594605, PMID:9814506). Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone/21-hydroxyprogesterone, namely 11-beta hydroxylation followed with two successive oxidations at C18 to yield 18-hydroxy and then 18-aldehyde derivatives, resulting in the formation of aldosterone (PMID:11856349, PMID:23322723, PMID:1594605, PMID:9814506). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PMID:11856349, PMID:23322723, PMID:1594605, PMID:9814506). | ||
|---|---|---|---|
| Other names | Cytochrome P450 11B2, mitochondrial, Aldosterone synthase, ALDOS, EC 1.14.15.4, EC 1.14.15.5, Aldosterone-synthesizing enzyme, CYPXIB2, Cytochrome P-450Aldo, Cytochrome P-450C18, Steroid 18-hydroxylase, CYP11B2 | ||
| Cellular localization | Mitochondrion Inner Membrane, Peripheral Membrane | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P19099 | ||
| Product name | Anti-CYP11B2 / Cytochrome P450 11B2 Antibody (Aldosterone synthase) | ||
|---|---|---|---|
| Catalog No | IGX-43269 | ||
| Supplier’s Catalog No | IGX-43269 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cytochrome P450 11B2, mitochondrial protein (25-503AA) | ||
| Specificity | CYP11B2 antibody detects endogenous level of CYP11B2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved