Anti-TRIB3 Antibody
Catalog No : IGX-43237
262.00€
188.00€
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| Description | Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PMID:15781252, PMID:15775988). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PMID:15781252, PMID:15775988). May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PMID:15781252, PMID:15775988). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity . Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation . May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 . Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PMID:12736262). Interacts with MAPK kinases and regulates activation of MAP kinases (PMID:15299019). Can inhibit APOBEC3A editing of nuclear DNA (PMID:22977230). | ||
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| Other names | Tribbles homolog 3, TRB-3, Neuronal cell death-inducible putative kinase, SINK, p65-interacting inhibitor of NF-kappa-B, TRIB3, C20orf97 NIPK SKIP3 TRB3 | ||
| Cellular localization | Nucleus | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q96RU7 | ||
| Product name | Anti-TRIB3 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43237 | ||
| Supplier’s Catalog No | IGX-43237 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Tribbles homolog 3 protein (152-325AA) | ||
| Specificity | TRIB3 antibody detects endogenous level of TRIB3 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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