Anti-ZRANB3 Antibody
Catalog No : IGX-43234
262.00€
188.00€
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| Description | DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634, PMID:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PMID:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PMID:22705370, PMID:22704558). | ||
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| Other names | DNA annealing helicase and endonuclease ZRANB3, Annealing helicase 2, AH2, Zinc finger Ran-binding domain-containing protein 3, [Includes: DNA annealing helicase ZRANB3, EC 3.6.4.-, Endonuclease ZRANB3, EC 3.1.-.-,], ZRANB3 | ||
| Cellular localization | Chromosome, Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q5FWF4 | ||
| Product name | Anti-ZRANB3 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43234 | ||
| Supplier’s Catalog No | IGX-43234 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human DNA annealing helicase and endonuclease ZRANB3 protein (370-624AA) | ||
| Specificity | ZRANB3 antibody detects endogenous level of ZRANB3 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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