Anti-PTPRS Antibody
Catalog No : IGX-43174
262.00€
188.00€
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| Description | Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PMID:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PMID:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 . Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases . Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PMID:26231120). | ||
|---|---|---|---|
| Other names | Receptor-type tyrosine-protein phosphatase S, R-PTP-S, EC 3.1.3.48, Receptor-type tyrosine-protein phosphatase sigma, R-PTP-sigma, PTPRS | ||
| Cellular localization | Membrane, Single-Pass Type I Membrane, Axon, Perikaryon, Synaptic Vesicle Membrane, Synaptosome, Postsynaptic Density, Neuron Projection, Growth Cone | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q13332 | ||
| Product name | Anti-PTPRS Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43174 | ||
| Supplier’s Catalog No | IGX-43174 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Receptor-type tyrosine-protein phosphatase S protein (25-128AA) | ||
| Specificity | PTPRS antibody detects endogenous level of PTPRS protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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