Anti-PTPN4 Antibody
Catalog No : IGX-43100
237.00€
175.00€
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| Description | Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PMID:25825441, PMID:27246854). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PMID:20086240). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PMID:25825441). Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway . May act at junctions between the membrane and the cytoskeleton. | ||
|---|---|---|---|
| Other names | Tyrosine-protein phosphatase non-receptor type 4, EC 3.1.3.48, Protein-tyrosine phosphatase MEG1, MEG, PTPase-MEG1, PTPN4 | ||
| Cellular localization | Membrane, Peripheral Membrane, , Cytoskeleton, Cytoplasm | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P29074 | ||
| Product name | Anti-PTPN4 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43100 | ||
| Supplier’s Catalog No | IGX-43100 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Tyrosine-protein phosphatase non-receptor type 4 protein (1-240AA) | ||
| Specificity | PTPN4 antibody detects endogenous level of PTPN4 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions ( provided antibody remains sterile). | ||
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