Anti-DNAJB2 Antibody
Catalog No : IGX-42985
237.00€
175.00€
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| Description | Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PMID:7957263, PMID:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PMID:15936278, PMID:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PMID:12754272, PMID:20889486, PMID:21719532, PMID:22396390, PMID:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PMID:15936278). | ||
|---|---|---|---|
| Other names | DnaJ homolog subfamily B member 2, Heat shock 40 kDa protein 3, Heat shock protein J1, HSJ-1, DNAJB2, HSJ1 HSPF3 | ||
| Cellular localization | Nucleus, Cytoplasm, Endoplasmic Reticulum Membrane, Lipid-Anchor, | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P25686 | ||
| Product name | Anti-DNAJB2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42985 | ||
| Supplier’s Catalog No | IGX-42985 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human DnaJ homolog subfamily B member 2 protein (215-324AA) | ||
| Specificity | DNAJB2 antibody detects endogenous level of DNAJB2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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