Anti-ARIH2 Antibody
Catalog No : IGX-42680
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PMID:16118314, PMID:17646546, PMID:19340006, PMID:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets . The initial ubiquitin is then elongated . E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PMID:24076655). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PMID:16118314, PMID:17646546, PMID:19340006). May play a role in myelopoiesis (PMID:19340006). | ||
|---|---|---|---|
| Other names | E3 ubiquitin-protein ligase ARIH2, ARI-2, Protein ariadne-2 homolog, EC 2.3.2.27, RING-type E3 ubiquitin transferase ARIH2, Triad1 protein, ARIH2, ARI2 TRIAD1 | ||
| Cellular localization | Cytoplasm, Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O95376 | ||
| Product name | Anti-ARIH2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42680 | ||
| Supplier’s Catalog No | IGX-42680 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human E3 ubiquitin-protein ligase ARIH2 protein (194-493AA) | ||
| Specificity | ARIH2 antibody detects endogenous level of ARIH2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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