Anti-NMNAT1 Antibody
Catalog No : IGX-42575
237.00€
175.00€
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| Description | Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP (PMID:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PMID:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PMID:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+ (PMID:17402747). For the pyrophosphorolytic activity, prefers NAD+ and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PMID:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PMID:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PMID:27257257). Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NaADP+ (PMID:17402747). Protects against axonal degeneration following mechanical or toxic insults . | ||
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| Other names | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, NMN/NaMN adenylyltransferase 1, EC 2.7.7.1, EC 2.7.7.18, Nicotinamide-nucleotide adenylyltransferase 1, NMN adenylyltransferase 1, Nicotinate-nucleotide adenylyltransferase 1, NaMN adenylyltransferase 1, NMNAT1, NMNAT | ||
| Cellular localization | Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9HAN9 | ||
| Product name | Anti-NMNAT1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42575 | ||
| Supplier’s Catalog No | IGX-42575 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 protein (1-279AA) | ||
| Specificity | NMNAT1 antibody detects endogenous level of NMNAT1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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