Anti-LGALS8 Antibody
Catalog No : IGX-42555
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PMID:22246324, PMID:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PMID:22246324, PMID:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PMID:22246324, PMID:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PMID:22246324). Also required to restrict infection of Picornaviridae viruses (PMID:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PMID:21288902). | ||
|---|---|---|---|
| Other names | Galectin-8, Gal-8, Po66 carbohydrate-binding protein, Po66-CBP, Prostate carcinoma tumor antigen 1, PCTA-1, LGALS8 | ||
| Cellular localization | Cytosol, Cytoplasmic Vesicle | ||
| Research area | Cancer | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O00214 | ||
| Product name | Anti-LGALS8 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42555 | ||
| Supplier’s Catalog No | IGX-42555 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Galectin-8 protein (20-317AA) | ||
| Specificity | LGALS8 antibody detects endogenous level of LGALS8 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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