Anti-KHDRBS3 Antibody
Catalog No : IGX-42553
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PMID:10564820, PMID:19561594, PMID:26758068). Involved in splice site selection of vascular endothelial growth factor (PMID:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer . Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PMID:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity . May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing . Can bind FABP9 mRNA . May play a role as a negative regulator of cell growth. Inhibits cell proliferation. | ||
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| Other names | KH domain-containing, RNA-binding, signal transduction-associated protein 3, RNA-binding protein T-Star, Sam68-like mammalian protein 2, SLM-2, Sam68-like phosphotyrosine protein, KHDRBS3, SALP SLM2 | ||
| Cellular localization | Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O75525 | ||
| Product name | Anti-KHDRBS3 Antibody | ||
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| Catalog No | IGX-42553 | ||
| Supplier’s Catalog No | IGX-42553 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human KH domain-containing, RNA-binding, signal transduction-associated protein 3 protein (177-346AA) | ||
| Specificity | KHDRBS3 antibody detects endogenous level of KHDRBS3 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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