Anti-N6AMT1 Antibody
Catalog No : IGX-42463
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic (PMID:18539146, PMID:21193388, PMID:30017583). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PMID:18539146) . Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PMID:18539146, PMID:20606008). Also acts as a N6-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N6-methyladenosine) (PMID:30017583). N6-methyladenosine (m6A) DNA is significantly enriched in exonic regions and is associated with gene transcriptional activation (PMID:30017583). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PMID:21193388, PMID:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PMID:25997655). | ||
|---|---|---|---|
| Other names | HemK methyltransferase family member 2, EC 2.1.1.-, M.HsaHemK2P, N,6,-adenine-specific DNA methyltransferase 1, N6AMT1, C21orf127 HEMK2 | ||
| Cellular localization | Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9Y5N5 | ||
| Product name | Anti-N6AMT1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42463 | ||
| Supplier’s Catalog No | IGX-42463 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human HemK methyltransferase family member 2 protein (1-186AA) | ||
| Specificity | N6AMT1 antibody detects endogenous level of N6AMT1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved