Anti-CYP2J2 / Cytochrome P450 2J2 Antibody
Catalog No : IGX-42419
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PMID:8631948, PMID:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PMID:8631948, PMID:19965576). Catalyzes the epoxidation of double bonds of PUFA (PMID:8631948, PMID:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PMID:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PMID:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PMID:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PMID:23959307). Catalyzes the sulfoxidation of fenbedazole (PMID:19923256). | ||
|---|---|---|---|
| Other names | Cytochrome P450 2J2, EC 1.14.14.1, Arachidonic acid epoxygenase, CYPIIJ2, CYP2J2 | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Peripheral Membrane, Microsome Membrane, Peripheral Membrane | ||
| Research area | Metabolism, Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P51589 | ||
| Product name | Anti-CYP2J2 / Cytochrome P450 2J2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42419 | ||
| Supplier’s Catalog No | IGX-42419 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cytochrome P450 2J2 protein (328-502AA) | ||
| Specificity | CYP2J2 antibody detects endogenous level of CYP2J2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved