Anti-NOV Antibody
Catalog No : IGX-42396
237.00€
175.00€
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| Description | Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PMID:15181016, PMID:15611078, PMID:12695522, PMID:21344378, PMID:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PMID:12695522, PMID:21344378, PMID:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PMID:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PMID:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PMID:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PMID:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PMID:15611078). Involved in bone regeneration as a negative regulator . Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PMID:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion . Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PMID:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis . Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PMID:21871891). | ||
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| Other names | Protein NOV homolog, NovH, CCN family member 3, Insulin-like growth factor-binding protein 9, IBP-9, IGF-binding protein 9, IGFBP-9, Nephroblastoma-overexpressed gene protein homolog, NOV, CCN3 IGFBP9 NOVH | ||
| Cellular localization | Cytoplasm, Gap Junction, Secreted | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P48745 | ||
| Product name | Anti-NOV Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42396 | ||
| Supplier’s Catalog No | IGX-42396 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Protein NOV homolog protein (32-357AA) | ||
| Specificity | NOV antibody detects endogenous level of NOV protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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