Anti-PARL Antibody
Catalog No : IGX-42339
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals . Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PMID:22354088). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (PMID:14732705, PMID:17116872). | ||
|---|---|---|---|
| Other names | Presenilins-associated rhomboid-like protein, mitochondrial, EC 3.4.21.105, Mitochondrial intramembrane cleaving protease PARL, [Cleaved into: P-beta, Pbeta,], PARL, PSARL | ||
| Cellular localization | Mitochondrion Inner Membrane, Multi-Pass Membrane, Nucleus | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9H300 | ||
| Product name | Anti-PARL Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42339 | ||
| Supplier’s Catalog No | IGX-42339 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Presenilins-associated rhomboid-like protein, mitochondrial protein (1-170AA) | ||
| Specificity | PARL antibody detects endogenous level of PARL protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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