Anti-AKAP8L Antibody
Catalog No : IGX-42322
237.00€
175.00€
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| Description | Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PMID:10748171, PMID:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PMID:10761695, PMID:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PMID:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PMID:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PMID:16980585). May be involved in regulation of pre-mRNA splicing (PMID:17594903). (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity. | ||
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| Other names | A-kinase anchor protein 8-like, AKAP8-like protein, Helicase A-binding protein 95, HAP95, Homologous to AKAP95 protein, HA95, Neighbor of A-kinase-anchoring protein 95, Neighbor of AKAP95, AKAP8L, NAKAP NAKAP95 | ||
| Cellular localization | Nucleus, Cytoplasm | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9ULX6 | ||
| Product name | Anti-AKAP8L Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42322 | ||
| Supplier’s Catalog No | IGX-42322 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human A-kinase anchor protein 8-like protein (1-240AA) | ||
| Specificity | AKAP8L antibody detects endogenous level of AKAP8L protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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