Anti-TRPV4 Antibody
Catalog No : IGX-42315
237.00€
175.00€
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| Description | Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PMID:18826956, PMID:18695040, PMID:29899501). Also activated by heat, low pH, citrate and phorbol esters (PMID:16293632, PMID:18826956, PMID:18695040, PMID:25256292, PMID:20037586, PMID:21964574). Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PMID:12724311, PMID:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers . Acts as a regulator of intracellular Ca2+ in synoviocytes (PMID:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PMID:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PMID:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes . Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes . Together with AQP5, controls regulatory volume decrease in salivary epithelial cells . Required for normal development and maintenance of bone and cartilage (PMID:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PMID:29899501). Isoform 5: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. Isoform 2: Lacks channel activity, due to impaired oligomerization and intracellular retention. Isoform 4: Lacks channel activity, due to impaired oligomerization and intracellular retention. Isoform 6: Lacks channel activity, due to impaired oligomerization and intracellular retention. (Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X. (Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X. (Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X. | ||
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| Other names | Transient receptor potential cation channel subfamily V member 4, TrpV4, Osm-9-like TRP channel 4, OTRPC4, Transient receptor potential protein 12, TRP12, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, VRL-2, Vanilloid receptor-related osmotically-activated channel, VR-OAC, TRPV4, VRL2 VROAC | ||
| Cellular localization | Membrane, Apical Membrane, Multi-Pass Membrane, Adherens Junction, Cilium, Membrane, Endoplasmic Reticulum | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9HBA0 | ||
| Product name | Anti-TRPV4 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42315 | ||
| Supplier’s Catalog No | IGX-42315 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Transient receptor potential cation channel subfamily V member 4 protein (1-230AA) | ||
| Specificity | TRPV4 antibody detects endogenous level of TRPV4 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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