Anti-GSDME / Gasdermin-E Antibody
Catalog No : IGX-42227
237.00€
175.00€
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| Description | Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 (PMID:16897187, PMID:18223688). Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis (PMID:28459430, PMID:27281216). Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate (PMID:28459430). Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents (PMID:28045099). Exhibits bactericidal activity (PMID:27281216). | ||
|---|---|---|---|
| Other names | Gasdermin-E, Inversely correlated with estrogen receptor expression 1, ICERE-1, Non-syndromic hearing impairment protein 5, [Cleaved into: Gasdermin-E, N-terminal, GSDME-NT, Gasdermin-E, C-terminal, GSDME-CT,], GSDME, DFNA5 ICERE1 | ||
| Cellular localization | Membrane, Cytosol | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O60443 | ||
| Product name | Anti-GSDME / Gasdermin-E Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42227 | ||
| Supplier’s Catalog No | IGX-42227 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Gasdermin-E protein (1-260AA) | ||
| Specificity | GSDME antibody detects endogenous level of GSDME protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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