Anti-CALHM1 Antibody
Catalog No : IGX-42199
237.00€
175.00€
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| Description | Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes . Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways . Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) . Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca2+ concentration (PMID:22711817, PMID:23300080). Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca2+, Na+ and K+, as well as permeation of monovalent anions (PMID:22711817). Acts as an activator of the ERK1 and ERK2 cascade (PMID:23345406). Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (PMID:21574960). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner (PMID:18585350). | ||
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| Other names | Calcium homeostasis modulator protein 1, Protein FAM26C, CALHM1, FAM26C | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Multi-Pass Membrane, Membrane, Basolateral Membrane | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q8IU99 | ||
| Product name | Anti-CALHM1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42199 | ||
| Supplier’s Catalog No | IGX-42199 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Calcium homeostasis modulator protein 1 protein (202-346AA) | ||
| Specificity | CALHM1 antibody detects endogenous level of CALHM1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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