Anti-BLK Antibody
Catalog No : IGX-42165
237.00€
175.00€
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| Description | Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling . B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors . Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation . Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor . Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' . Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PMID:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation . Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation . In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PMID:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PMID:30356214). | ||
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| Other names | Tyrosine-protein kinase Blk, EC 2.7.10.2, B lymphocyte kinase, p55-Blk, BLK | ||
| Cellular localization | Membrane, Lipid-Anchor | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P51451 | ||
| Product name | Anti-BLK Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42165 | ||
| Supplier’s Catalog No | IGX-42165 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Tyrosine-protein kinase Blk protein (1-280AA) | ||
| Specificity | BLK antibody detects endogenous level of BLK protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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