Anti-HTR2B Antibody
Catalog No : IGX-42128
237.00€
175.00€
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| Description | G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PMID:8143856, PMID:7926008, PMID:8078486, PMID:8882600, PMID:18703043, PMID:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PMID:8143856, PMID:7926008, PMID:8078486, PMID:12970106, PMID:18703043, PMID:23519210, PMID:23519215, PMID:24357322, PMID:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PMID:8143856, PMID:8078486, PMID:8882600, PMID:23519215, PMID:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PMID:23519215, PMID:28129538). Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores (PMID:8143856, PMID:8078486, PMID:8882600, PMID:18703043, PMID:23519215, PMID:28129538). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain . Plays a role in the regulation of behavior, including impulsive behavior (PMID:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine . | ||
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| Other names | 5-hydroxytryptamine receptor 2B, 5-HT-2B, 5-HT2B, Serotonin receptor 2B, HTR2B | ||
| Cellular localization | Membrane, Multi-Pass Membrane, Synaptosome | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P41595 | ||
| Product name | Anti-HTR2B Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42128 | ||
| Supplier’s Catalog No | IGX-42128 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human 5-hydroxytryptamine receptor 2B protein (382-481AA) | ||
| Specificity | HTR2B antibody detects endogenous level of HTR2B protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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