Anti-CYP4A11 Antibody
Catalog No : IGX-42106
237.00€
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| Description | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PMID:7679927, PMID:1739747, PMID:8914854, PMID:10553002, PMID:10660572, PMID:15611369). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PMID:7679927, PMID:1739747, PMID:8914854, PMID:10553002, PMID:10660572, PMID:15611369). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid (PMID:10553002, PMID:10660572). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PMID:7679927, PMID:1739747, PMID:8914854, PMID:15611369). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PMID:10620324, PMID:10660572, PMID:15611369). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PMID:7679927). May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PMID:18182499). Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PMID:15145985). Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PMID:18065749). Has little activity toward prostaglandins A1 and E1 (PMID:7679927). | ||
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| Other names | Cytochrome P450 4A11, 20-hydroxyeicosatetraenoic acid synthase, 20-HETE synthase, CYP4AII, CYPIVA11, Cytochrome P-450HK-omega, Cytochrome P450HL-omega, Fatty acid omega-hydroxylase, Lauric acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase, EC 1.14.13.205, CYP4A11, CYP4A2 | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Peripheral Membrane, Microsome Membrane, Peripheral Membrane | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q02928 | ||
| Product name | Anti-CYP4A11 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42106 | ||
| Supplier’s Catalog No | IGX-42106 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cytochrome P450 4A11 protein (1-200AA) | ||
| Specificity | CYP4A11 antibody detects endogenous level of CYP4A11 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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