Anti-BIN1 Antibody
Catalog No : IGX-42032
237.00€
175.00€
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| Description | Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PMID:24755653). Is a negative regulator of endocytosis . Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PMID:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates . May be involved in the regulation of MYC activity and the control cell proliferation (PMID:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PMID:28893863). | ||
|---|---|---|---|
| Other names | Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, BIN1, AMPHL | ||
| Cellular localization | T-Tubule, Cytoplasm, Endosome, Nucleus | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O00499 | ||
| Product name | Anti-BIN1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42032 | ||
| Supplier’s Catalog No | IGX-42032 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Myc box-dependent-interacting protein 1 protein (414-593AA) | ||
| Specificity | BIN1 antibody detects endogenous level of BIN1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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