Anti-CADM1 / Cell adhesion molecule 1 Antibody
Catalog No : IGX-42010
237.00€
175.00€
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| Description | Mediates homophilic cell-cell adhesion in a Ca2+-independent manner (PMID:22438059, PMID:12050160). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca2+-independent manner . Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PMID:15811952). In mast cells, may mediate attachment to and promote communication with nerves (PMID:15905536). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PMID:22438059). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node . Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells . Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells . Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly . May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons . May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa . Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PMID:11279526, PMID:12234973). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PMID:12920246). | ||
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| Other names | Cell adhesion molecule 1, Immunoglobulin superfamily member 4, IgSF4, Nectin-like protein 2, NECL-2, Spermatogenic immunoglobulin superfamily, SgIgSF, Synaptic cell adhesion molecule, SynCAM, Tumor suppressor in lung cancer 1, TSLC-1, CADM1, IGSF4 IGSF4A NECL2 SYNCAM TSLC1 | ||
| Cellular localization | Membrane, Single-Pass Type I Membrane, Synapse | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9BY67 | ||
| Product name | Anti-CADM1 / Cell adhesion molecule 1 Antibody | ||
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| Catalog No | IGX-42010 | ||
| Supplier’s Catalog No | IGX-42010 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cell adhesion molecule 1 protein (45-344AA) | ||
| Specificity | CADM1 antibody detects endogenous level of CADM1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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