Anti-TP53BP1 Antibody
Catalog No : IGX-41933
237.00€
175.00€
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| Description | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PMID:12364621, PMID:22553214, PMID:23333306, PMID:17190600, PMID:21144835, PMID:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PMID:22553214, PMID:23727112, PMID:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PMID:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PMID:23760478, PMID:28241136, PMID:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PMID:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR . In contrast, it is not required for classic NHEJ and V(D)J recombination . Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PMID:23727112). | ||
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| Other names | TP53-binding protein 1, 53BP1, p53-binding protein 1, p53BP1, TP53BP1 | ||
| Cellular localization | Chromosome, Kinetochore, Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q12888 | ||
| Product name | Anti-TP53BP1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41933 | ||
| Supplier’s Catalog No | IGX-41933 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Tumor suppressor p53-binding protein 1 protein (1758-1972AA) | ||
| Specificity | TP53BP1 antibody detects endogenous level of TP53BP1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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