Anti-NRP1 Antibody
Catalog No : IGX-41896
237.00€
175.00€
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| Description | Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins (PMID:9288753, PMID:9529250, PMID:10688880). It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB (PMID:9288753, PMID:9529250, PMID:10688880). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development . Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PMID:30623799). Binds VEGF-165 and may inhibit its binding to cells (PMID:10748121, PMID:26503042). May induce apoptosis by sequestering VEGF-165 (PMID:10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. | ||
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| Other names | Neuropilin-1, Vascular endothelial cell growth factor 165 receptor, CD antigen CD304, NRP1, NRP VEGF165R | ||
| Cellular localization | Secreted, Mitochondrion Membrane, Single-Pass Type I Membrane, Cytoplasm | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O14786 | ||
| Product name | Anti-NRP1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41896 | ||
| Supplier’s Catalog No | IGX-41896 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Neuropilin-1 protein (684-923AA) | ||
| Specificity | NRP1 antibody detects endogenous level of NRP1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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