Anti-CBX4 Antibody
Catalog No : IGX-41895
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PMID:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PMID:22825850). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PMID:12167701, PMID:19636380, PMID:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PMID:12167701, PMID:19636380, PMID:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) . Plays a role in the lineage differentiation of the germ layers in embryonic development . | ||
|---|---|---|---|
| Other names | E3 SUMO-protein ligase CBX4, EC 2.3.2.-, Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2, CBX4 | ||
| Cellular localization | Nucleus, Nucleus Speckle | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O00257 | ||
| Product name | Anti-CBX4 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41895 | ||
| Supplier’s Catalog No | IGX-41895 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human E3 SUMO-protein ligase CBX4 protein (401-560AA) | ||
| Specificity | CBX4 antibody detects endogenous level of CBX4 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved