Anti-SF3B6 Antibody
Catalog No : IGX-41892
262.00€
188.00€
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| Description | Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PMID:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (PMID:12234937). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (PMID:16432215). Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (PMID:16432215). | ||
|---|---|---|---|
| Other names | Splicing factor 3B subunit 6, Pre-mRNA branch site protein p14, SF3b 14 kDa subunit, SF3B14a, Spliceosome-associated protein, 14-kDa, Splicing factor 3b, subunit 6, 14kDa, SF3B6, SAP14 SF3B14 SF3B14A | ||
| Cellular localization | Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9Y3B4 | ||
| Product name | Anti-SF3B6 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41892 | ||
| Supplier’s Catalog No | IGX-41892 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Splicing factor 3B subunit 6 protein (1-125AA) | ||
| Specificity | SF3B6 antibody detects endogenous level of SF3B6 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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