Anti-APPL1 Antibody
Catalog No : IGX-41855
262.00€
188.00€
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| Description | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PMID:26583432, PMID:15016378, PMID:26073777, PMID:19661063, PMID:10490823). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PMID:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 . Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages . Regulates TLR4 signaling in activated macrophages . Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PMID:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PMID:26073777, PMID:19661063, PMID:24879834). Required for fibroblast migration through HGF cell signaling . Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PMID:19433865). | ||
|---|---|---|---|
| Other names | DCC-interacting protein 13-alpha, Dip13-alpha, Adapter protein containing PH domain, PTB domain and leucine zipper motif 1, APPL1, APPL DIP13A KIAA1428 | ||
| Cellular localization | Nucleus, Early Endosome Membrane, Peripheral Membrane, Endosome, Cytoplasm, Ruffle, Phagosome | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9UKG1 | ||
| Product name | Anti-APPL1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41855 | ||
| Supplier’s Catalog No | IGX-41855 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human DCC-interacting protein 13-alpha protein (214-495AA) | ||
| Specificity | APPL1 antibody detects endogenous level of APPL1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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