Anti-SETX Antibody
Catalog No : IGX-41498
262.00€
188.00€
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| Description | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PMID:19515850, PMID:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PMID:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PMID:19515850, PMID:21700224, PMID:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation . Involved in DNA double-strand breaks damage response generated by oxidative stress (PMID:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PMID:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) . May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PMID:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PMID:21576111). | ||
|---|---|---|---|
| Other names | Probable helicase senataxin, EC 3.6.4.-, Amyotrophic lateral sclerosis 4 protein, SEN1 homolog, Senataxin, SETX, ALS4 KIAA0625 SCAR1 | ||
| Cellular localization | Nucleus, Nucleoplasm, Nucleolus, Cytoplasm, Chromosome, Telomere, Axon, Growth Cone | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q7Z333 | ||
| Product name | Anti-SETX Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41498 | ||
| Supplier’s Catalog No | IGX-41498 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Probable helicase senataxin protein (2401-2677AA) | ||
| Specificity | SETX antibody detects endogenous level of SETX protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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