Anti-GCKR / Glucokinase regulatory protein Antibody
Catalog No : IGX-41350
262.00€
188.00€
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| Description | Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PMID:23621087, PMID:23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PMID:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PMID:23621087, PMID:23733961). | ||
|---|---|---|---|
| Other names | Glucokinase regulatory protein, GKRP, Glucokinase regulator, GCKR | ||
| Cellular localization | Mitochondrion, Nucleus, Cytoplasm | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q14397 | ||
| Product name | Anti-GCKR / Glucokinase regulatory protein Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41350 | ||
| Supplier’s Catalog No | IGX-41350 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Glucokinase regulatory protein (1-625AA) | ||
| Specificity | GCKR antibody detects endogenous level of GCKR protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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