Anti-DNASE1L3 Antibody
Catalog No : IGX-41345
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends . Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA (PMID:9070308, PMID:9714828, PMID:14646506, PMID:10807908, PMID:27293190). Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis (PMID:23229555, PMID:24312463). The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells . Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PMID:27293190). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) . NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation . Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation . | ||
|---|---|---|---|
| Other names | Deoxyribonuclease gamma, DNase gamma, EC 3.1.21.-, DNase I homolog protein DHP2, Deoxyribonuclease I-like 3, DNase I-like 3, Liver and spleen DNase, LS-DNase, LSD, DNASE1L3, DHP2 DNAS1L3 | ||
| Cellular localization | Secreted, Nucleus, Endoplasmic Reticulum | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q13609 | ||
| Product name | Anti-DNASE1L3 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41345 | ||
| Supplier’s Catalog No | IGX-41345 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Deoxyribonuclease gamma protein (21-305AA) | ||
| Specificity | DNASE1L3 antibody detects endogenous level of DNASE1L3 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved