Anti-LRRC32 Antibody
Catalog No : IGX-41342
262.00€
188.00€
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| Description | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PMID:19750484, PMID:19651619, PMID:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PMID:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PMID:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PMID:19750484, PMID:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) . | ||
|---|---|---|---|
| Other names | Transforming growth factor beta activator LRRC32, Garpin, Glycoprotein A repetitions predominant, GARP, Leucine-rich repeat-containing protein 32, LRRC32, D11S833E | ||
| Cellular localization | Membrane, Single-Pass Type I Membrane, Cell Surface | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q14392 | ||
| Product name | Anti-LRRC32 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41342 | ||
| Supplier’s Catalog No | IGX-41342 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Transforming growth factor beta activator LRRC32 protein (301-500AA) | ||
| Specificity | LRRC32 antibody detects endogenous level of LRRC32 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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