Anti-SRSF10 Antibody
Catalog No : IGX-41322
262.00€
188.00€
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| Description | Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PMID:11684676, PMID:12419250, PMID:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PMID:14765198). Required for splicing repression in M-phase cells and after heat shock (PMID:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PMID:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PMID:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PMID:12419250). | ||
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| Other names | Serine/arginine-rich splicing factor 10, 40 kDa SR-repressor protein, SRrp40, FUS-interacting serine-arginine-rich protein 1, Splicing factor SRp38, Splicing factor, arginine/serine-rich 13A, TLS-associated protein with Ser-Arg repeats, TASR, TLS-associated protein with SR repeats, TLS-associated serine-arginine protein, TLS-associated SR protein, SRSF10, FUSIP1 FUSIP2 SFRS13A TASR | ||
| Cellular localization | Nucleus Speckle, Cytoplasm | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O75494 | ||
| Product name | Anti-SRSF10 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41322 | ||
| Supplier’s Catalog No | IGX-41322 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Serine/arginine-rich splicing factor 10 protein (1-183AA) | ||
| Specificity | SRSF10 antibody detects endogenous level of SRSF10 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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