Anti-MKI67 Antibody
Catalog No : IGX-41276
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PMID:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PMID:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PMID:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PMID:10878551). Does not contribute to the internal structure of mitotic chromosomes . May play a role in chromatin organization (PMID:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). | ||
|---|---|---|---|
| Other names | Proliferation marker protein Ki-67, Antigen identified by monoclonal antibody Ki-67, Antigen KI-67, Antigen Ki67, MKI67 | ||
| Cellular localization | Nucleus, Nucleolus, Chromosome | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P46013 | ||
| Product name | Anti-MKI67 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41276 | ||
| Supplier’s Catalog No | IGX-41276 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Proliferation marker protein Ki-67 protein (3120-3256AA) | ||
| Specificity | MKI67 antibody detects endogenous level of MKI67 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved