Anti-PLB / Phospholamban Antibody
Catalog No : IGX-41053
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. | ||
|---|---|---|---|
| Other names | Cardiac phospholamban, PLN | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Single-Pass Membrane, Mitochondrion Membrane | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P26678 | ||
| Product name | Anti-PLB / Phospholamban Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41053 | ||
| Supplier’s Catalog No | IGX-41053 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200, ELISA: Use at an assay dependent concentration. | ||
| Molecular weight | 6 KDa | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cardiac phospholamban protein (1-52AA) | ||
| Specificity | PLN antibody detects endogenous level of PLN protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved