Anti-APLN Antibody
Catalog No : IGX-40799
262.00€
188.00€
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| Description | Endogenous ligand for the apelin receptor (APLNR) (PMID:10525157). Drives internalization of the apelin receptor . Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR . Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis . Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates . Plays a role in early coronary blood vessels formation . Mediates myocardial contractility in an ERK1/2-dependent manner . May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior . (Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection (PMID:11090199). Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR (PMID:11090199). Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives (PMID:11090199). | ||
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| Other names | Apelin, APJ endogenous ligand, [Cleaved into: Apelin-36, Apelin-31, Apelin-28, Apelin-13], APLN, APEL | ||
| Cellular localization | Secreted, Extracellular Space | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9ULZ1 | ||
| Product name | Anti-APLN Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40799 | ||
| Supplier’s Catalog No | IGX-40799 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:10-1:100 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Peptide sequence from Human Apelin protein | ||
| Specificity | APLN antibody detects endogenous level of APLN protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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