Anti-SESN2 Antibody
Catalog No : IGX-40742
262.00€
188.00€
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| Description | Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PMID:18692468, PMID:25263562, PMID:25457612, PMID:26449471, PMID:26612684, PMID:26586190). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PMID:26449471, PMID:26586190). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PMID:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PMID:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PMID:18692468). Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PMID:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PMID:15105503). However, this could not be confirmed (PMID:19113821). | ||
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| Other names | Sestrin-2, EC 1.11.1.15, Hypoxia-induced gene, SESN2, Hi95 SEST2 | ||
| Cellular localization | Cytoplasm | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P58004 | ||
| Product name | Anti-SESN2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40742 | ||
| Supplier’s Catalog No | IGX-40742 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Peptide sequence from Human Sestrin-2 protein (42-61AA) | ||
| Specificity | SESN2 antibody detects endogenous level of SESN2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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