Anti-CAVIN1 Antibody
Catalog No : IGX-40707
262.00€
188.00€
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| Description | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PMID:18056712, PMID:18191225, PMID:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (PMID:18056712, PMID:18191225, PMID:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A . | ||
|---|---|---|---|
| Other names | Caveolae-associated protein 1, Cavin-1, Polymerase I and transcript release factor, CAVIN1, PTRF | ||
| Cellular localization | Nucleus, Microsome, Endoplasmic Reticulum, Membrane, Cytosol, Mitochondrion, Caveola | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q6NZI2 | ||
| Product name | Anti-CAVIN1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40707 | ||
| Supplier’s Catalog No | IGX-40707 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Caveolae-associated protein 1 protein (12-44AA) | ||
| Specificity | CAVIN1 antibody detects endogenous level of CAVIN1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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