Anti-OSBP Antibody
Catalog No : IGX-40706
262.00€
188.00€
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| Description | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PMID:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PMID:15746430, PMID:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PMID:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PMID:18450749). | ||
|---|---|---|---|
| Other names | Oxysterol-binding protein 1, OSBP, OSBP1 | ||
| Cellular localization | Golgi Apparatus Membrane, Peripheral Membrane, Cytosol, Endoplasmic Reticulum Membrane, Peripheral Membrane, Perinuclear Region | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P22059 | ||
| Product name | Anti-OSBP Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40706 | ||
| Supplier’s Catalog No | IGX-40706 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Oxysterol-binding protein 1 protein (628-802AA) | ||
| Specificity | OSBP antibody detects endogenous level of OSBP protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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