Anti-GABRG2 Antibody
Catalog No : IGX-40703
262.00€
188.00€
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| Description | Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PMID:2538761, PMID:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PMID:23909897, PMID:25489750, PMID:27864268). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer . The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PMID:23909897, PMID:25489750). The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity . Functions also as histamine receptor and mediates cellular responses to histamine . | ||
|---|---|---|---|
| Other names | Gamma-aminobutyric acid receptor subunit gamma-2, GABA,A, receptor subunit gamma-2, GABRG2 | ||
| Cellular localization | Postsynaptic Membrane, Multi-Pass Membrane, Membrane, Dendrite, Cytoplasmic Vesicle Membrane | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P18507 | ||
| Product name | Anti-GABRG2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40703 | ||
| Supplier’s Catalog No | IGX-40703 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Gamma-aminobutyric acid receptor subunit gamma-2 protein (42-108AA) | ||
| Specificity | GABRG2 antibody detects endogenous level of GABRG2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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