Anti-CAV1 / Caveolin 1 Antibody
Catalog No : IGX-40688
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | May act as a scaffolding protein within caveolar membranes (PMID:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PMID:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity . Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PMID:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway . Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PMID:25893292). | ||
|---|---|---|---|
| Other names | Caveolin-1, CAV1, CAV | ||
| Cellular localization | Golgi Apparatus Membrane, Peripheral Membrane, Trans-Golgi Network, Membrane, Caveola, Membrane Raft | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q03135 | ||
| Product name | Anti-CAV1 / Caveolin 1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40688 | ||
| Supplier’s Catalog No | IGX-40688 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Peptide sequence from Human Caveolin-1 protein (26-43AA) | ||
| Specificity | CAV1 antibody detects endogenous level of CAV1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved