Anti-SPPL2B Antibody
Catalog No : IGX-40649
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PMID:16829952, PMID:16829951, PMID:17965014, PMID:19114711, PMID:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PMID:16829952, PMID:16829951). May play a role in the regulation of innate and adaptive immunity (PMID:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PMID:23132852). | ||
|---|---|---|---|
| Other names | Signal peptide peptidase-like 2B, SPP-like 2B, SPPL2b, EC 3.4.23.-, Intramembrane protease 4, IMP-4, Presenilin homologous protein 4, PSH4, Presenilin-like protein 1, SPPL2B, IMP4 KIAA1532 PSL1 | ||
| Cellular localization | Golgi Apparatus Membrane, Multi-Pass Membrane, Endosome Membrane, Lysosome Membrane, Membrane, Membrane, Lumenal Side | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q8TCT7 | ||
| Product name | Anti-SPPL2B Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40649 | ||
| Supplier’s Catalog No | IGX-40649 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Signal peptide peptidase-like 2B protein (492-592AA) | ||
| Specificity | SPPL2B antibody detects endogenous level of SPPL2B protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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