| Description |
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PMID:9703499, PMID:10330172, PMID:10751406, PMID:11279239, PMID:12115244, PMID:12748283, PMID:15187101, PMID:15634918, PMID:17030620, PMID:16702957, PMID:20702587, PMID:20221403, PMID:21775632, PMID:27193233, PMID:23644599, PMID:25815583). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PMID:15687258, PMID:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PMID:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PMID:11719186, PMID:12748283, PMID:15687258, PMID:16364915). Self regulates by destabilizing its own mRNA (PMID:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PMID:10330172, PMID:10751406, PMID:12115244, PMID:15187101, PMID:15634918, PMID:17030620, PMID:16702957, PMID:19188452, PMID:20702587, PMID:20221403, PMID:21775632, PMID:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages . Plays also a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PMID:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PMID:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) . Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PMID:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA . Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PMID:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PMID:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PMID:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PMID:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing . Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages . Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion . Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PMID:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PMID:26926077). |
| Other names |
mRNA decay activator protein ZFP36, G0/G1 switch regulatory protein 24, Growth factor-inducible nuclear protein NUP475, Tristetraprolin, Zinc finger protein 36, Zfp-36, ZFP36, G0S24 NUP475 RNF162A TIS11A TTP |
