Anti-PARP14 Antibody
Catalog No : IGX-40499
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PMID:16061477, PMID:27796300, PMID:18851833, PMID:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PMID:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PMID:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PMID:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PMID:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PMID:27796300). Mono-ADP-ribosylates PARP9 (PMID:27796300). | ||
|---|---|---|---|
| Other names | Poly [ADP-ribose] polymerase 14, PARP-14, EC 2.4.2.30, ADP-ribosyltransferase diphtheria toxin-like 8, ARTD8, B aggressive lymphoma protein 2, PARP14, BAL2 KIAA1268 | ||
| Cellular localization | Nucleus, Cytoplasm | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q460N5 | ||
| Product name | Anti-PARP14 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40499 | ||
| Supplier’s Catalog No | IGX-40499 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Poly [ADP-ribose] polymerase 14 protein (1600-1712AA) | ||
| Specificity | PARP14 antibody detects endogenous level of PARP14 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved