Anti-SH3GLB1 Antibody
Catalog No : IGX-40316
262.00€
188.00€
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| Description | May be required for normal outer mitochondrial membrane dynamics (PMID:15452144). Required for coatomer-mediated retrograde transport in certain cells . May recruit other proteins to membranes with high curvature. May promote membrane fusion (PMID:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PMID:16227588). Isoform 1 acts proapoptotic in fibroblasts . Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PMID:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PMID:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PMID:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability . | ||
|---|---|---|---|
| Other names | Endophilin-B1, Bax-interacting factor 1, Bif-1, SH3 domain-containing GRB2-like protein B1, SH3GLB1, KIAA0491 | ||
| Cellular localization | Golgi Apparatus Membrane, Peripheral Membrane, Mitochondrion Outer Membrane, Cytoplasm, Autophagosome Membrane, Midbody | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9Y371 | ||
| Product name | Anti-SH3GLB1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40316 | ||
| Supplier’s Catalog No | IGX-40316 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Endophilin-B1 protein (1-365AA) | ||
| Specificity | SH3GLB1 antibody detects endogenous level of SH3GLB1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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