Recombinant Human InsR (N-GST tag)
Catalog No : IGX-RP876
366.40€
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| Product name | Recombinant Human InsR (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP876 | ||
| Supplier’s Catalog No | IGX-RP876 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 70 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | HHF5, CD220 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | InsR is the insulin receptor tyrosine kinase that is involved in insulin signaling. InsR is post-translationally cleaved into two chains, a and ß that are covalently linked. Binding of insulin to the InsR stimulates glucose uptake . Insulin receptor signaling helps to maintain fuel homeostasis and prevent diabetes. Studies have shown that a conditional knockout of insulin receptor substrate 2 (IRS2) in mouse pancreas ß cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. InsR signaling also increases the regeneration of adult ß cells and the central control of nutrient homeostasis . | ||
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