Imugex

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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			GMCSF, Granulocyte-macrophage colony-stimulating factor, CSF-2, Molgramostin, Sargramostim, pluripoietin-alpha, Recombinant Human Granulocyte Macrophage Colony Stimulating Factor (CSF2)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Human GM-CSF was lyophilized from a 0.2 μm filtered solution in PBS, pH 7.0.
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			GM-CSF is a monomeric protein of 127 amino acids with two glycosylation sites. The protein is synthesized as a precursor of 144 amino acids, which included a hydrophobic secretory signal sequence at the amino terminal end. The sugar moiety is not required for the full spectrum of biological activities. Non-glycosylated and glycosylated GM-CSF show the same activities in vitro. Fully glycosylated GM-CSF is biologically more active in vivo than the non-glycosylated protein. This protein is secreted together with other factors by T cells and macrophages following cell activation by antigens or mitogens. Approximately 90% of the secreted colony stimulating activities are due to GM-CSF.