Imugex

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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			Tumor necrosis factor, Cachectin, TNF, Tumor necrosis factor ligand superfamily member 2, TNF-a<br/>Recombinant Human TNF-alpha (TNFA)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			TNF-a was lyophilized from a 0.2μm filtered concentrated (1.0 mg/mL) solution in PBS, pH 7.2.
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			Tumor Necrosis Factor is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides. Cells expressing CD4 secrete TNF-alpha while CD8(+) cells secrete little or no TNF-alpha. Stimulated peripheral neutrophilic granulocytes but also unstimulated cells and also a number of transformed cell lines, astrocytes, microglial cells, smooth muscle cells, and fibroblasts also secrete TNF. Human milk also contains this factor. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL-2, GM-CSF, SP, Bradykinin, immune complexes, inhibitors of cyclooxygenase, and PAF (platelet activating factor). Human TNF-alpha is a non-glycosylated protein of 17 kDa and a length of 157 amino acids. Murine TNF-alpha is N-glycosylated. Homology with TNF-beta is approximately 30%. TNF-alpha forms dimers and trimers.