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Categories: Peptides & Proteins / Proteins

Product name			Recombinant Human Stem Cell Factor (KITLG)
Catalog No			IGX-RP227
Supplier’s Catalog No			IGX-RP227
Supplier			ImuGeX
Source antigen			CHO cells
Reactivity			Human
Cross reactivity
Applications
Molecular weight			18

Storage			-70°C
Other names			SCF, Kit ligand, c-Kit Ligand, Mast cell growth factor, MGF
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Lyophilized from a 0.2 μm filtered solution in PBS pH 7.0
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			SCF is a stromal cell-derived cytokine synthesized by fibroblasts and other cell types. SCF promotes proliferation and early differentiation of cells at the level of multipotent stem cells. It has been suggested that SCF is essential for optimal production of various hematopoietic lineages, mainly because of its ability to prevent apoptosis when co-stimulated with other cytokines. The receptor for SCF, designated SCFR (CD117) is the oncogene designated as KIT. The biological activities of SCF are considerably synergised by colony stimulating factors; GM-CSF and G-CSF, and by IL7, EPO and some other growth and differentiation factors. In combination with IL7, SCF stimulates the proliferation of pre-B cells. SCF is also a potent chemoattractant for cells expressing the kit receptor. Recombinant Human SCF is a glycosylated, monomeric protein (contains intra-chain disulfide bonds) that runs at approximately 25 kDa in a reducing SDS-PAGE.